Abstract
Bioassay-guided fractionation of the roots of Ardisia cornudentata Mez (Myrsinaceae) led to the isolation of three new compounds, 3-methoxy-2-methyl-5-pentylphenol
(1), 3-methoxy-2-methyl-5-(1′-ketopentyl)phenol (2), and cornudoside (3), together with twenty-six known compounds. Their structures were elucidated by analysis
of spectroscopic data. Thirteen of these isolates, 1, 2, 4–6, 9–15, and 21 showed antitubercular activities against Mycobacterium tuberculosis H37RV in vitro, with MIC values of 2.5–60 µg/mL. Two alkyl benzoquinones, ardisianone (7) and cornudentanone (8), were reported for their selective cytotoxic activity against the NCI-H460 cancer
cell line (IC50 values of 2.3, 2.5 µg/mL).
Key words
Ardisia cornudentata
- Myrsinaceae - resorcinol - benzenoid C‐glucoside - antitubercular activities - cytotoxicity
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Prof. Dr. Ih-Sheng Chen
Graduate Institute of Natural Products
College of Pharmacy
Kaohsiung Medical University
100 Shih-Chuan 1st Road
807 Kaohsiung
Taiwan
Phone: + 88 6 73 12 11 01 ext. 21 91
Fax: + 88 6 73 21 06 83
Email: m635013@kmu.edu.tw
